The mouse as a model for human biology: a resource guide for complex trait analysis

被引：214

作者：

Peters, Luanne L. ^{[1
]}

Robledo, Raymond F. ^{[1
]}

Bult, Carol J. ^{[1
]}

Churchill, Gary A. ^{[1
]}

Paigen, Beverly J. ^{[1
]}

Svenson, Karen L. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 01期

关键词：

D O I：

10.1038/nrg2025

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse has been a powerful force in elucidating the genetic basis of human physiology and pathophysiology. From its beginnings as the model organism for cancer research and transplantation biology to the present, when dissection of the genetic basis of complex disease is at the forefront of genomics research, an enormous and remarkable mouse resource infrastructure has accumulated. This review summarizes those resources and provides practical guidelines for their use, particularly in the analysis of quantitative traits.

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收藏

页码：58 / 69

页数：12

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