International Union of Pharmacology.: LXII.: The NR1H and NR1I receptors:: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor

被引：169

作者：

Moore, David D. ^{[1
]}

Kato, Shigeaki

Xie, Wen

Mangelsdorf, David J.

Schmidt, Daniel R.

Xiao, Rui

Kliewer, Steven A.

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo, Japan

[3] Univ Pittsburgh, Ctr Pharmacogenet, Pittsburgh, PA USA

[4] Univ Texas, SW Med Ctr, Dept Pharmacol, Howard Hughes Med Inst, Dallas, TX 75235 USA

来源：

PHARMACOLOGICAL REVIEWS | 2006年 / 58卷 / 04期

关键词：

D O I：

10.1124/pr.58.4.6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.

引用

页码：742 / 759

页数：18

共 205 条

[91] Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue [J].

Laffitte, BA ;

Chao, LC ;

Li, J ;

Walczak, R ;

Hummasti, S ;

Joseph, SB ;

Castrillo, A ;

Wilpitz, DC ;

Mangelsdorf, DJ ;

Collins, JL ;

Saez, E ;

Tontonoz, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5419-5424

[92] LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes [J].

Laffitte, BA ;

Repa, JJ ;

Joseph, SB ;

Wilpiltz, DC ;

Kast, HR ;

Mangelsdorf, DJ ;

Tontonoz, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (02) :507-512

[93] The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions [J].

Laffitte, BA ;

Joseph, SB ;

Chen, MY ;

Castrillo, A ;

Repa, J ;

Wilpitz, D ;

Mangelsdorf, D ;

Tontonoz, P .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (06) :2182-2191

[94] Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics [J].

Lamba, J ;

Lamba, V ;

Schuetz, E .

CURRENT DRUG METABOLISM, 2005, 6 (04) :369-383

[95] The farnesoid X-receptor is an essential regulator of cholesterol homeostasis [J].

Lambert, G ;

Amar, MJA ;

Guo, G ;

Brewer, HB ;

Gonzalez, FJ ;

Sinal, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (04) :2563-2570

[96] The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-α and -β genes [J].

Landrier, JF ;

Eloranta, JJ ;

Vavricka, SR ;

Kullak-Ublick, GA .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 290 (03) :G476-G485

[97] α-Crystallin is a target gene of the farnesoid X-activated receptor in human livers [J].

Lee, FY ;

Kast-Woelbern, HR ;

Chang, J ;

Luo, GZ ;

Jones, SA ;

Fishbein, MC ;

Edwards, PA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (36) :31792-31800

[98] Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway [J].

Lehmann, JM ;

Kliewer, SA ;

Moore, LB ;

SmithOliver, TA ;

Oliver, BB ;

Su, JL ;

Sundseth, SS ;

Winegar, DA ;

Blanchard, DE ;

Spencer, TA ;

Willson, TM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (06) :3137-3140

[99] The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions [J].

Lehmann, JM ;

McKee, DD ;

Watson, MA ;

Willson, TM ;

Moore, JT ;

Kliewer, SA .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (05) :1016-1023

[100] Macrophage liver x receptor is required for antiatherogenic activity of LXR agonists [J].

Levin, N ;

Bischoff, ED ;

Daige, CL ;

Thomas, D ;

Vu, CT ;

Heyman, RA ;

Tangirala, RK ;

Schulman, IG .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (01) :135-142

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