International Union of Pharmacology.: LXII.: The NR1H and NR1I receptors:: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor

被引：169

作者：

Moore, David D. ^{[1
]}

Kato, Shigeaki

Xie, Wen

Mangelsdorf, David J.

Schmidt, Daniel R.

Xiao, Rui

Kliewer, Steven A.

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo, Japan

[3] Univ Pittsburgh, Ctr Pharmacogenet, Pittsburgh, PA USA

[4] Univ Texas, SW Med Ctr, Dept Pharmacol, Howard Hughes Med Inst, Dallas, TX 75235 USA

来源：

PHARMACOLOGICAL REVIEWS | 2006年 / 58卷 / 04期

关键词：

D O I：

10.1124/pr.58.4.6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.

引用

页码：742 / 759

页数：18

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