Diversity of LEF/TCF action in development and disease

被引：325

作者：

Arce, L. ^{[1
]}

Yokoyama, N. N. ^{[1
]}

Waterman, M. L. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA

来源：

ONCOGENE | 2006年 / 25卷 / 57期

关键词：

LEF; TCF; Wnt; beta-catenin;

D O I：

10.1038/sj.onc.1210056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in the nucleus by recruiting beta-catenin and its co-activators to Wnt response elements (WREs) of target genes. This activity is important during development but its misregulation plays a role in disease such as cancer, where overactive Wnt signaling drives LEF/TCFs to transform cells. The size of the LEF/TCF family is small: approximately four members in vertebrates and one orthologous form in flies, worms and hydra. However, size belies complexity. The LEF/TCF family exhibits extensive patterns of alternative splicing, alternative promoter usage and activities of repression, as well as activation. Recent work from numerous laboratories has highlighted how this complexity has important biological consequences in development and disease.

引用

页码：7492 / 7504

页数：13

共 118 条

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