The application of DNA microarrays in gene expression analysis

被引:159
作者
van Hal, NLW
Vorst, O
van Houwelingen, AMML
Kok, EJ
Peijnenburg, A
Aharoni, A
van Tunen, AJ
Keijer, J
机构
[1] RIKILT, State Inst Qual Control Agr Prod, Gene Express & Detect Ctr, NL-6700 AE Wageningen, Netherlands
[2] Plant Res Int, Gene Express & Detect Ctr, NL-6700 AA Wageningen, Netherlands
关键词
DNA microarray technology; gene expression; food safety; gene discovery; pathway engineering; review;
D O I
10.1016/S0168-1656(00)00204-2
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
DNA microarray technology is a new and powerful technology that will substantially increase the speed of molecular biological research. This paper gives a survey of PNA microarray technology and its use in gene expression studies. The technical aspects and their potential improvements are discussed. These comprise array manufacturing and design, array hybridisation, scanning, and data handling. Furthermore, it Is discussed how DNA microarrays can be applied in the working fields of: safety, functionality and health of food and gene discovery and pathway engineering in plants. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:271 / 280
页数:10
相关论文
共 39 条
[1]   METHOD FOR DETECTION OF SPECIFIC RNAS IN AGAROSE GELS BY TRANSFER TO DIAZOBENZYLOXYMETHYL-PAPER AND HYBRIDIZATION WITH DNA PROBES [J].
ALWINE, JC ;
KEMP, DJ ;
STARK, GR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5350-5354
[2]   Proteomics: quantitative and physical mapping of cellular proteins [J].
Blackstock, WP ;
Weir, MP .
TRENDS IN BIOTECHNOLOGY, 1999, 17 (03) :121-127
[3]   The complete genome sequence of Escherichia coli K-12 [J].
Blattner, FR ;
Plunkett, G ;
Bloch, CA ;
Perna, NT ;
Burland, V ;
Riley, M ;
ColladoVides, J ;
Glasner, JD ;
Rode, CK ;
Mayhew, GF ;
Gregor, J ;
Davis, NW ;
Kirkpatrick, HA ;
Goeden, MA ;
Rose, DJ ;
Mau, B ;
Shao, Y .
SCIENCE, 1997, 277 (5331) :1453-+
[4]   Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].
不详 .
SCIENCE, 1998, 282 (5396) :2012-2018
[5]   Human and mouse proteomic databases: novel resources in the protein universe [J].
Celis, JE ;
Ostergaard, M ;
Jensen, NA ;
Gromova, I ;
Rasmussen, HH ;
Gromov, P .
FEBS LETTERS, 1998, 430 (1-2) :64-72
[6]   Accessing genetic information with high-density DNA arrays [J].
Chee, M ;
Yang, R ;
Hubbell, E ;
Berno, A ;
Huang, XC ;
Stern, D ;
Winkler, J ;
Lockhart, DJ ;
Morris, MS ;
Fodor, SPA .
SCIENCE, 1996, 274 (5287) :610-614
[7]   Expression profiling using cDNA microarrays [J].
Duggan, DJ ;
Bittner, M ;
Chen, YD ;
Meltzer, P ;
Trent, JM .
NATURE GENETICS, 1999, 21 (Suppl 1) :10-14
[8]   Electric field directed nucleic acid hybridization on microchips [J].
Edman, CF ;
Raymond, DE ;
Wu, DJ ;
Tu, EG ;
Sosnowski, RG ;
Butler, WF ;
Nerenberg, M ;
Heller, MJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (24) :4907-4914
[9]   PNA HYBRIDIZES TO COMPLEMENTARY OLIGONUCLEOTIDES OBEYING THE WATSON-CRICK HYDROGEN-BONDING RULES [J].
EGHOLM, M ;
BUCHARDT, O ;
CHRISTENSEN, L ;
BEHRENS, C ;
FREIER, SM ;
DRIVER, DA ;
BERG, RH ;
KIM, SK ;
NORDEN, B ;
NIELSEN, PE .
NATURE, 1993, 365 (6446) :566-568
[10]   Cluster analysis and display of genome-wide expression patterns [J].
Eisen, MB ;
Spellman, PT ;
Brown, PO ;
Botstein, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868