The application of DNA microarrays in gene expression analysis

被引：159

作者：

van Hal, NLW

Vorst, O

van Houwelingen, AMML

Kok, EJ

Peijnenburg, A

Aharoni, A

van Tunen, AJ

Keijer, J

机构：

[1] RIKILT, State Inst Qual Control Agr Prod, Gene Express & Detect Ctr, NL-6700 AE Wageningen, Netherlands

[2] Plant Res Int, Gene Express & Detect Ctr, NL-6700 AA Wageningen, Netherlands

来源：

JOURNAL OF BIOTECHNOLOGY | 2000年 / 78卷 / 03期

关键词：

DNA microarray technology; gene expression; food safety; gene discovery; pathway engineering; review;

D O I：

10.1016/S0168-1656(00)00204-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA microarray technology is a new and powerful technology that will substantially increase the speed of molecular biological research. This paper gives a survey of PNA microarray technology and its use in gene expression studies. The technical aspects and their potential improvements are discussed. These comprise array manufacturing and design, array hybridisation, scanning, and data handling. Furthermore, it Is discussed how DNA microarrays can be applied in the working fields of: safety, functionality and health of food and gene discovery and pathway engineering in plants. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：271 / 280

页数：10

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