Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects

被引：54

作者：

Barbieri, Michelangela ^{[1
]}

Paolisso, Giuseppe ^{[1
]}

Kimura, Masayuki ^{[2
]}

Gardner, Jeffrey P. ^{[2
]}

Boccardi, Virginia ^{[1
]}

Papa, Michela ^{[1
]}

Hjelmborg, Jacob V. ^{[3
,4
]}

Christensen, Kaare ^{[3
,4
]}

Brimacombe, Michael ^{[2
]}

Nawrot, Tim S. ^{[5
]}

Staessen, Jan A. ^{[6
,7
]}

Pollak, Michael N. ^{[8
]}

Aviv, Abraham ^{[2
]}

机构：

[1] Univ Naples 2, Dept Geriatr Med & Metab Dis, I-80138 Naples, Italy

[2] Univ Med & Dent New Jersey, Ctr Human Dev & Aging, Newark, NJ 07103 USA

[3] Univ So Denmark, Epidemiol Unit, Inst Publ Hlth, Danish Twin Registry & Danish Aging Res Ctr, Odense, Denmark

[4] Univ So Denmark, Stat Unit, Inst Publ Hlth, Danish Twin Registry & Danish Aging Res Ctr, Odense, Denmark

[5] Hasselt Univ, Sch Life Sci, Res Grp Environm Biol, Diepenbeek, Belgium

[6] Univ Louvain, Dept Cardiovasc Dis, Studies Coordinating Ctr, Div Hypertens & Cardiovasc Rehabil, Louvain, Belgium

[7] Maastricht Univ, Dept Epidemiol, Maastricht, Netherlands

[8] McGill Univ, Jewish Gen Hosp, Dept Oncol, Montreal, PQ H3T 1E2, Canada

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2009年 / 130卷 / 11-12期

关键词：

Aging; Human; Telomere length; lGF-1; Insulin resistance; ANGIOTENSIN-ALDOSTERONE SYSTEM; LIFE-SPAN; OXIDATIVE STRESS; CAENORHABDITIS-ELEGANS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; BINDING PROTEIN-3; GROWTH-FACTORS; SERUM-LEVELS; OLDEST-OLD;

D O I：

10.1016/j.mad.2009.10.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mutations that inhibit the insulin-like growth factor-1 (IGF-1) extend the lifespan of worms, flies and mice. However, it appears that relatively low circulating levels of IGF-1 in humans are associated with aging-related diseases and diminished longevity. As leukocyte telomere length (LTL) is ostensibly a biomarker of human aging, we examined the relationship between LTL and blood IGF-1 in a healthy cohort. Our sample comprised 476 healthy, unrelated Caucasians (208 men and 268 women), aged 16104 years, living in the West Coast of Southern Italy. We measured LTL by Southern blots and IGF-1 by enzyme-linked immunoassay. Both IGF-1 and LTL diminished with age (IGF-1. r = -0.601, P < 0.001; LTL, r = -0.706, P < 0.001). Age-adjusted LTL was positively associated with IGF-1 level throughout the age range of the cohort (r = 0.270, P < 0.001). IGF-1 accounted for about 10% of the inter-individual variation in LTL over and above the effect of age. Our findings suggest that both circulating IGF-1 and LTL are indices of healthy aging in humans. Further research will be necessary to establish whether LTL will ultimately be used in clinical settings as an index of healthy aging. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：771 / 776

页数：6

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