Quality assessment of tandem mass spectra based on cumulative intensity normalization

被引：37

作者：

Na, Seungjin ^{[1
]}

Paek, Eunok ^{[1
]}

机构：

[1] Univ Seoul, Dept Mech & Informat Engn, Seoul 130743, South Korea

来源：

JOURNAL OF PROTEOME RESEARCH | 2006年 / 5卷 / 12期

关键词：

tandem mass spectra; intensity normalization; spectral quality; peptide identification;

D O I：

10.1021/pr0603248

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A large proportion of MS/MS spectral analyses do not result in significant matches because their spectral quality is too poor to produce meaningful identification. Throughput of peptide identification can be greatly improved, if one can filter out, in advance, spectra that would lead to wrong identification. We introduce here an innovative approach to assess spectral quality utilizing a new spectral feature called Xrea, based on cumulative intensity normalization.

引用

页码：3241 / 3248

页数：8

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