Stabilization signals: a novel regulatory mechanism in the ubiquitin/proteasome system

被引：29

作者：

Dantuma, NP ^{[1
]}

Masucci, MG ^{[1
]}

机构：

[1] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

来源：

FEBS LETTERS | 2002年 / 529卷 / 01期

关键词：

degradation signal; proteolysis; neurodegeneration; domains; motifs;

D O I：

10.1016/S0014-5793(02)03252-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The turnover of cellular proteins is a highly organized process that involves spatially and temporally regulated degradation by the ubiquitin/proteasome system. It is generally acknowledged that the specificity of the process is determined by constitutive or conditional protein domains, the degradation signals, that target the substrate for proteasomal degradation. In this review, we discuss a new type of regulatory domain: the stabilization signal. A model is proposed according to which protein half-lives are determined by the interplay of counteracting degradation and stabilization signals. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：22 / 26

页数：5