A solid phase traceless synthesis of quinoxalinones

被引：52

作者：

Krchnák, V ^{[1
]}

Szabo, L ^{[1
]}

Vágner, J ^{[1
]}

机构：

[1] SIDDCO, Tucson, AZ 85747 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(00)00297-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solid-phase traceless synthesis of quinoxalinones in three combinatorial steps is reported. An aldehyde functionalized polystyrene resin was reductively alkylated by amino acid methyl esters, and then the resin bound secondary amines were reacted with o-fluoronitrobenzenes. The resulting o-nitroanilines were reduced by tin chloride to the dianilines, which spontaneously cyclized. The amide nitrogen of the dihydroquinoxalinones obtained was alkylated by alkyl halides. After cleavage from the resin, the dihydroquinoxalinones were air oxidized to quinoxalinones. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2835 / 2838

页数：4

共 7 条

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