Apparatus and method for cleavage of compounds from solid support by gaseous reagents

被引：8

作者：

Kerschen, A ^{[1
]}

Kanizsai, A ^{[1
]}

Botros, I ^{[1
]}

Krchnák, V ^{[1
]}

机构：

[1] SIDDCO, Tucson, AZ 85747 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 1999年 / 1卷 / 06期

关键词：

D O I：

10.1021/cc990026q

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polymer-supported library compounds have been cleaved from acid sensitive linkers using gaseous reagents hydrogen fluoride and hydrogen chloride. Compounds attached to Wang, Rink, AMEBA, and MBHA linkers were cleaved. The reaction gas container for gaseous cleavage was made of a polypropylene tube enclosed by two side-plates. Fast and reliable filling by a reagent gas was achieved by introducing the gas into the evacuated reaction container rather than gradually replacing the gas under atmospheric pressure.

引用

页码：480 / 484

页数：5

共 12 条

[1] GAS-PHASE CLEAVAGE OF PEPTIDES FROM A SOLID SUPPORT WITH AMMONIA VAPOR - APPLICATION IN SIMULTANEOUS MULTIPLE PEPTIDE-SYNTHESIS [J].