Harnessing Human Dendritic Cell Subsets to Design Novel Vaccines

被引：56

作者：

Banchereau, Jacques ^{[1
]}

Klechevsky, Eynav ^{[1
]}

Schmitt, Nathalie ^{[1
]}

Morita, Rimpei ^{[1
]}

Palucka, Karolina ^{[1
]}

Ueno, Hideki ^{[1
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

来源：

CANCER VACCINES | 2009年 / 1174卷

关键词：

dendritic cell; vaccine; immunology; CD34(+) HEMATOPOIETIC PROGENITORS; CORD BLOOD DIFFERENTIATE; LANGERHANS CELLS; IN-VIVO; T-CELLS; B-CELLS; ANTIGEN PRESENTATION; MEDIATED-IMMUNITY; CUTTING EDGE; RESPONSES;

D O I：

10.1111/j.1749-6632.2009.04999.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dendritic cells (DCs) orchestrate a repertoire of immune responses that endow resistance to infection and tolerance to self. DC plasticity and subsets are prominent determinants of the quality of elicited immune responses. Different DC subsets display different receptors and surface molecules and express different sets of cytokines/chemokines, all of which lead to distinct immunological outcomes. Recent findings on human DC subsets and their functional specialization have provided insights for the design of novel human vaccines.

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页码：24 / 32

页数：9

相关论文

共 44 条

[1] Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells [J].

Allan, RS ;

Smith, CM ;

Belz, GT ;

van Lint, AL ;

Wakim, LM ;

Heath, WR ;

Carbone, FR .

SCIENCE, 2003, 301 (5641) :1925-1928

[2] Cutaneous antigen priming via gene gun leads to skin-selective Th2 immune-inflammatory responses [J].

Alvarez, D ;

Harder, G ;

Fattouh, R ;

Sun, JF ;

Goncharova, S ;

Stämpfli, MR ;

Coyle, AJ ;

Bramson, JL ;

Jordana, M .

JOURNAL OF IMMUNOLOGY, 2005, 174 (03) :1664-1674

[3] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[4] The who, how and where of antigen presentation to B cells [J].

Batista, Facundo D. ;

Harwood, Naomi E. .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (01) :15-27

[5] Cell surface recycling of internalized antigen permits dendritic cell priming of B cells [J].

Bergtold, A ;

Desai, DD ;

Gavhane, A ;

Clyne, R .

IMMUNITY, 2005, 23 (05) :503-514

[6] Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus [J].

Blanco, P ;

Palucka, AK ;

Gill, M ;

Pascual, V ;

Banchereau, J .

SCIENCE, 2001, 294 (5546) :1540-1543

[7] Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells [J].

Bosnjak, L ;

Miranda-Saksena, M ;

Koelle, DM ;

Boadle, RA ;

Jones, CA ;

Cunningham, AL .

JOURNAL OF IMMUNOLOGY, 2005, 174 (04) :2220-2227

[8] Enhancing immune responses by targeting antigen to DC [J].

Caminschi, Irina ;

Lahoud, Mireille H. ;

Shortman, Ken .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (04) :931-938

[9] Plasmacytoid dendritic cell-specific receptor ILT7-FcεRIγ inhibits Toll-like receptor-induced interferon production [J].

Cao, Wei ;

Rosen, David B. ;

Ito, Tomoki ;

Bover, Laura ;

Bao, Musheng ;

Watanabe, Gokuran ;

Yao, Zhengbin ;

Zhang, Li ;

Lanier, Lewis L. ;

Liu, Yong-Jun .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (06) :1399-1405

[10] CD34(+) hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha .2. Functional analysis [J].

Caux, C ;

Massacrier, C ;

Vanbervliet, B ;

Dubois, B ;

Durand, I ;

Cella, M ;

Lanzavecchia, A ;

Banchereau, J .

BLOOD, 1997, 90 (04) :1458-1470

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