Dendritic cell subsets in primary and secondary T cell responses at body surfaces

被引:320
作者
Heath, William R. [1 ]
Carbone, Francis R. [1 ]
机构
[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia
关键词
HERPES-SIMPLEX-VIRUS; IN-VIVO DEPLETION; EPIDERMAL LANGERHANS CELLS; ANTIGEN-PRESENTING CELLS; MIXED LEUKOCYTE REACTION; STEADY-STATE CONDITIONS; BLOOD MONOCYTE SUBSETS; MOUSE LYMPH-NODES; CONTACT HYPERSENSITIVITY; EFFICIENT PRESENTATION;
D O I
10.1038/ni.1822
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We examine the role of dendritic cells subsets in immunity to peripheral infections, with emphasis on the differences in the regulation of primary and secondary T cell responses to viruses. Our major focus is on new developments in the understanding of immunity to infections of the skin and lung, which are crucial entry points for a variety of infectious pathogens. Initially we describe a diverse network of dendritic cell subsets, but then we argue for a more generalized model of reduced complexity.
引用
收藏
页码:1237 / 1244
页数:8
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