Dendritic cell subsets in primary and secondary T cell responses at body surfaces

被引：320

作者：

Heath, William R. ^{[1
]}

Carbone, Francis R. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 12期

关键词：

HERPES-SIMPLEX-VIRUS; IN-VIVO DEPLETION; EPIDERMAL LANGERHANS CELLS; ANTIGEN-PRESENTING CELLS; MIXED LEUKOCYTE REACTION; STEADY-STATE CONDITIONS; BLOOD MONOCYTE SUBSETS; MOUSE LYMPH-NODES; CONTACT HYPERSENSITIVITY; EFFICIENT PRESENTATION;

D O I：

10.1038/ni.1822

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examine the role of dendritic cells subsets in immunity to peripheral infections, with emphasis on the differences in the regulation of primary and secondary T cell responses to viruses. Our major focus is on new developments in the understanding of immunity to infections of the skin and lung, which are crucial entry points for a variety of infectious pathogens. Initially we describe a diverse network of dendritic cell subsets, but then we argue for a more generalized model of reduced complexity.

引用

页码：1237 / 1244

页数：8

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