Vancomycin resistance in enterococci: reprogramming of the D-Ala-D-Ala ligases in bacterial peptidoglycan biosynthesis

被引：121

作者：

Healy, VL

Lessard, IAD

Roper, DI

Knox, JR

Walsh, CT

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Boehringer Ingelheim Canada Ltee, Biomega Div Rech, Laval, PQ H7S 2G5, Canada

[3] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[4] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA

来源：

CHEMISTRY & BIOLOGY | 2000年 / 7卷 / 05期

关键词：

D O I：

10.1016/S1074-5521(00)00116-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vancomycin binds to bacterial cell-wall intermediates to achieve its antibiotic effect. Infections of vancomycin-resistant enterococci are, however, becoming an increasing problem; the bacteria are resistant because they synthesize different cell-wall intermediates. The enzymes involved in cell-wall biosynthesis, therefore, are potential targets for combating this resistance. Recent biochemical and crystallographic results are providing mechanistic and structural details about some of these targets.

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页码：R109 / R119

页数：11

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共 63 条

[51] VanD-type glycopeptide-resistant Enterococcus faecium BM4339 [J].

Perichon, B ;

Reynolds, P ;

Courvalin, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (09) :2016-2018

[52] Gene vanXYc encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in vancomycin-resistant Enterococcus gallinarum BM4174 [J].

Reynolds, PE ;

Arias, CA ;

Courvalin, P .

MOLECULAR MICROBIOLOGY, 1999, 34 (02) :341-349

[53] STRUCTURE, BIOCHEMISTRY AND MECHANISM OF ACTION OF GLYCOPEPTIDE ANTIBIOTICS [J].

REYNOLDS, PE .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1989, 8 (11) :943-950

[54] GLYCOPEPTIDE RESISTANCE MEDIATED BY ENTEROCOCCAL TRANSPOSON TN1546 REQUIRES PRODUCTION OF VANX FOR HYDROLYSIS OF D-ALANYL-D-ALANINE [J].

REYNOLDS, PE ;

DEPARDIEU, F ;

DUTKAMALEN, S ;

ARTHUR, M ;

COURVALIN, P .

MOLECULAR MICROBIOLOGY, 1994, 13 (06) :1065-1070

[55] ACTIVE-SITE MAPPING OF ESCHERICHIA-COLI D-ALA-D-ALA LIGASE BY STRUCTURE-BASED MUTAGENESIS [J].

SHI, Y ;

WALSH, CT .

BIOCHEMISTRY, 1995, 34 (09) :2768-2776

[56] HOSPITAL-ACQUIRED INFECTIONS - DISEASES WITH INCREASINGLY LIMITED THERAPIES [J].

SWARTZ, MN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2420-2427

[57] Structure of carbamoyl phosphate synthetase: A journey of 96 angstrom from substrate to product [J].

Thoden, JB ;

Holden, HM ;

Wesenberg, G ;

Raushel, FM ;

Rayment, I .

BIOCHEMISTRY, 1997, 36 (21) :6305-6316

[58] CLUSTAL-W - IMPROVING THE SENSITIVITY OF PROGRESSIVE MULTIPLE SEQUENCE ALIGNMENT THROUGH SEQUENCE WEIGHTING, POSITION-SPECIFIC GAP PENALTIES AND WEIGHT MATRIX CHOICE [J].

THOMPSON, JD ;

HIGGINS, DG ;

GIBSON, TJ .

NUCLEIC ACIDS RESEARCH, 1994, 22 (22) :4673-4680

[59] MULTIPLE-ANTIBIOTIC-RESISTANT PATHOGENIC BACTERIA - A REPORT ON THE ROCKEFELLER-UNIVERSITY WORKSHOP [J].

TOMASZ, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (17) :1247-1251

[60] VANCOMYCIN RESISTANCE - DECODING THE MOLECULAR LOGIC [J].

WALSH, CT .

SCIENCE, 1993, 261 (5119) :308-309

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