Vancomycin resistance in enterococci: reprogramming of the D-Ala-D-Ala ligases in bacterial peptidoglycan biosynthesis

被引：121

作者：

Healy, VL

Lessard, IAD

Roper, DI

Knox, JR

Walsh, CT

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Boehringer Ingelheim Canada Ltee, Biomega Div Rech, Laval, PQ H7S 2G5, Canada

[3] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[4] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT 06269 USA

来源：

CHEMISTRY & BIOLOGY | 2000年 / 7卷 / 05期

关键词：

D O I：

10.1016/S1074-5521(00)00116-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vancomycin binds to bacterial cell-wall intermediates to achieve its antibiotic effect. Infections of vancomycin-resistant enterococci are, however, becoming an increasing problem; the bacteria are resistant because they synthesize different cell-wall intermediates. The enzymes involved in cell-wall biosynthesis, therefore, are potential targets for combating this resistance. Recent biochemical and crystallographic results are providing mechanistic and structural details about some of these targets.

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页码：R109 / R119

页数：11

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