Simultaneous alignment of short reads against multiple genomes

被引：144

作者：

Schneeberger, Korbinian ^{[1
]}

Hagmann, Joerg ^{[1
]}

Ossowski, Stephan ^{[1
]}

Warthmann, Norman ^{[1
]}

Gesing, Sandra ^{[2
]}

Kohlbacher, Oliver ^{[2
]}

Weigel, Detlef ^{[1
]}

机构：

[1] Max Planck Inst Dev Biol, Dept Mol Biol, D-72076 Tubingen, Germany

[2] Univ Tubingen, Ctr Bioinformat Tubingen ZBIT, D-72076 Tubingen, Germany

来源：

GENOME BIOLOGY | 2009年 / 10卷 / 09期

关键词：

ARABIDOPSIS-THALIANA; STRUCTURAL VARIATION; SHORT SEQUENCES; SEARCH; ULTRAFAST; DISCOVERY; DATABASES; PROGRAM;

D O I：

10.1186/gb-2009-10-9-r98

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genome resequencing with short reads generally relies on alignments against a single reference. GenomeMapper supports simultaneous mapping of short reads against multiple genomes by integrating related genomes (e. g., individuals of the same species) into a single graph structure. It constitutes the first approach for handling multiple references and introduces representations for alignments against complex structures. Demonstrated benefits include access to polymorphisms that cannot be identified by alignments against the reference alone. Download GenomeMapper at http://1001genomes.org.

引用

页数：12

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