Inhibition of fungal cell wall synthesizing enzymes by trans-cinnamaldehyde

被引：126

作者：

Bang, KH ^{[1
]}

Lee, DW ^{[1
]}

Park, HM ^{[1
]}

Rhee, YH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Nat Sci, Dept Microbiol, Taejon 305764, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2000年 / 64卷 / 05期

关键词：

beta-(1,3)-glucan synthase inhibitor; chitin synthase inhibitor; noncompetitive and mixed inhibition; trans-cinnamaldehyde;

D O I：

10.1271/bbb.64.1061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study examined the inhibitory effects of trans-cinnamaldehyde (CA), an aromatic aldehyde derived from Cinnamomi Cortex, on Saccharomyces cerevisiae cell wall synthesizing enzymes in vitro. This compound was found to be a noncompetitive inhibitor of beta-(1,3)-glucan synthase and a mixed inhibitor of chitin synthase 1 with 50% inhibitory concentrations (IC50) of 0.84 and 1.44 mM, respectively. Chitin synthases 2 and 3 were less sensitive than chitin synthase 1 to CA. CA can be useful as a model compound of cell wall inhibitors for the development of effective antifungal agents.

引用

页码：1061 / 1063

页数：3

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