Small synthetic inhibitors of cysteine proteases

被引：41

作者：

Rasnick, D

机构：

[1] Arris Pharmaceutical Corporation, South San Francisco, CA 94808

来源：

PERSPECTIVES IN DRUG DISCOVERY AND DESIGN | 1996年 / 6卷

关键词：

D O I：

10.1007/BF02174045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This article focuses on the development of small synthetic inhibitors of cysteine proteases since 1990. The emphasis is on the design of selective cysteine protease inhibitors as research tools and as potential therapeutic agents. The mechanisms of inhibition of the new compounds, where appropriate, are discussed, and also how a knowledge of the differences in mechanisms between cysteine and serine proteases may be exploited in the design of selective inhibitors.

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页码：47 / 63

页数：17

相关论文

共 101 条

[31] ASPARTYL ALPHA-((1-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOL-5-YL)OXY)METHYL KETONES AS INTERLEUKIN-1-BETA CONVERTING-ENZYME INHIBITORS - SIGNIFICANCE OF THE P-1 AND P-3 AMIDO NITROGENS FOR ENZYME-PEPTIDE INHIBITOR BINDING [J].

DOLLE, RE ;

SINGH, J ;

RINKER, J ;

HOYER, D ;

PRASAD, CVC ;

GRAYBILL, TL ;

SALVINO, JM ;

HELASZEK, CT ;

MILLER, RE ;

ATOR, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (23) :3863-3866

[32] PEPTIDE ALDEHYDES AND NITRILES AS TRANSITION-STATE ANALOG INHIBITORS OF CYSTEINE PROTEASES [J].

DUFOUR, E ;

STORER, AC ;

MENARD, R .

BIOCHEMISTRY, 1995, 34 (28) :9136-9143

[33] MOLECULAR-ORBITAL STUDIES OF THE STRUCTURE AND REACTIVITY OF MODEL SUBSTRATE INTERMEDIATES IN THE DEACYLATION OF THE CYSTEINE PROTEASE PAPAIN [J].

DUNCAN, GD ;

HUBER, CP ;

WELSH, WJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (14) :5784-5794

[34] THE ROLE OF CYSTEINE PROTEASES IN HYPOXIA-INDUCED RAT RENAL PROXIMAL TUBULAR INJURY [J].

EDELSTEIN, CL ;

WIEDER, ED ;

YAQOOB, MM ;

GENGARO, PE ;

BURKE, TJ ;

NEMENOFF, RA ;

SCHRIER, RW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7662-7666

[35]

Ermer A, 1990, J Enzyme Inhib, V4, P35, DOI 10.3109/14756369009030386

[36]

ESSER RE, 1993, J RHEUMATOL, V20, P1176

[37] CYSTEINE PROTEINASE-INHIBITORS DECREASE ARTICULAR-CARTILAGE AND BONE DESTRUCTION IN CHRONIC INFLAMMATORY ARTHRITIS [J].

ESSER, RE ;

ANGELO, RA ;

MURPHEY, MD ;

WATTS, LM ;

THORNBURG, LP ;

PALMER, JT ;

TALHOUK, JW ;

SMITH, RE .

ARTHRITIS AND RHEUMATISM, 1994, 37 (02) :236-247

[38]

ETHERINGTON DJ, 1988, BRIT J EXP PATHOL, V69, P281

[39] MECHANISM OF ASSOCIATION OF N-ACETYL-L-PHENYLALANYLGLYCINAL TO PAPAIN [J].

FRANKFATER, A ;

KUPPY, T .

BIOCHEMISTRY, 1981, 20 (19) :5517-5524

[40] MULTIPLY CONVERGENT SYNTHESES VIA CONJUGATE-ADDITION REACTIONS TO CYCLOALKENYL SULFONES [J].

FUCHS, PL ;

BRAISH, TF .

CHEMICAL REVIEWS, 1986, 86 (05) :903-917

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