Small synthetic inhibitors of cysteine proteases

被引：41

作者：

Rasnick, D

机构：

[1] Arris Pharmaceutical Corporation, South San Francisco, CA 94808

来源：

PERSPECTIVES IN DRUG DISCOVERY AND DESIGN | 1996年 / 6卷

关键词：

D O I：

10.1007/BF02174045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This article focuses on the development of small synthetic inhibitors of cysteine proteases since 1990. The emphasis is on the design of selective cysteine protease inhibitors as research tools and as potential therapeutic agents. The mechanisms of inhibition of the new compounds, where appropriate, are discussed, and also how a knowledge of the differences in mechanisms between cysteine and serine proteases may be exploited in the design of selective inhibitors.

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页码：47 / 63

页数：17

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