The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts

被引：362

作者：

Paulsen, IT

Seshadri, R

Nelson, KE

Eisen, JA

Heidelberg, JF

Read, TD

Dodson, RJ

Umayam, L

Brinkac, LM

Beanan, MJ

Daugherty, SC

Deboy, RT

Durkin, AS

Kolonay, JF

Madupu, R

Nelson, WC

Ayodeji, B

Kraul, M

Shetty, J

Malek, J

Van Aken, SE

Riedmuller, S

Tettelin, H

Gill, SR

White, O

Salzberg, SL

Hoover, DL

Lindler, LE

Halling, SM

Boyle, SM

Fraser, CM

机构：

[1] Inst Genom Res, Rockville, MD 20850 USA

[2] Johns Hopkins Univ, Baltimore, MD 21218 USA

[3] Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA

[4] USDA ARS, Natl Anim Dis Ctr, Ames, IA 50010 USA

[5] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Ctr Mol Med & Infect Dis, Blacksburg, VA 24061 USA

[6] George Washington Univ, Sch Med, Dept Pharmacol & Microbiol, Washington, DC 20037 USA

[7] George Washington Univ, Sch Med, Dept Trop Med, Washington, DC 20037 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 20期

关键词：

D O I：

10.1073/pnas.192319099

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

引用

页码：13148 / 13153

页数：6

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