Waltzing transporters and 'the dance macabre' between humans and bacteria

被引：139

作者：

Lomovskaya, Olga

Zgurskaya, Helen I.

Totrov, Maxim

Watkins, William J.

机构：

[1] Mpex Pharmaceut Inc, San Diego, CA 92109 USA

[2] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

[3] Molsoft LLC, La Jolla, CA 92037 USA

[4] Gilead Sci Inc, Foster City, CA 94404 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2007年 / 6卷 / 01期

关键词：

D O I：

10.1038/nrd2200

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Multidrug-resistance efflux pumps - in particular those belonging to the resistance-nodulation-cell-division (RND) family of transporters, with their unusually high degree of substrate promiscuity - significantly restrict the effectiveness of antibacterial therapy. Recent years have heralded remarkable insights into the structure and mechanisms of these fascinating molecular machines. Here, we review recent advances in the field and describe various approaches used in combating efflux-mediated resistance.

引用

收藏

页码：56 / 65

页数：10

相关论文

共 104 条

[1] The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication [J].

Aendekerk, S ;

Diggle, SP ;

Song, Z ;

Hoiby, N ;

Cornelis, P ;

Williams, P ;

Cámara, M .

MICROBIOLOGY-SGM, 2005, 151 :1113-1125

[2] Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli [J].

Aires, JR ;

Nikaido, H .

JOURNAL OF BACTERIOLOGY, 2005, 187 (06) :1923-1929

[3] Crystal structure of the drug discharge outer membrane protein, OprM, of Pseudomonas aeruginosa -: Dual modes of membrane anchoring and occluded cavity end [J].

Akama, H ;

Kanemaki, M ;

Yoshimura, M ;

Tsukihara, T ;

Kashiwagi, T ;

Yoneyama, H ;

Narita, S ;

Nakagawa, A ;

Nakae, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (51) :52816-52819

[4] Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa [J].

Akama, H ;

Matsuura, T ;

Kashiwagi, S ;

Yoneyama, H ;

Narita, SI ;

Tsukihara, T ;

Nakagawa, A ;

Nakae, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (25) :25939-25942

[5] The hedgehog pathway and basal cell carcinomas [J].

Bale, AE ;

Yu, KP .

HUMAN MOLECULAR GENETICS, 2001, 10 (07) :757-762

[6] Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps [J].

Bohnert, HA ;

Kern, WV .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :849-852

[7] Directed evolution of a bacterial efflux pump:: Adaptation of the E-coli TolC exit duct to the Pseudomonas MexAB translocase [J].

Bokma, Evert ;

Koronakis, Eva ;

Lobedanz, Sune ;

Hughes, Colin ;

Koronakis, Vassilis .

FEBS LETTERS, 2006, 580 (22) :5339-5343

[8] The Burkholderia pseudomallei BpeAB-OprB efflux pump:: Expression and impact on quorum sensing and virulence [J].

Chan, YY ;

Chua, KL .

JOURNAL OF BACTERIOLOGY, 2005, 187 (14) :4707-4719

[9] New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant Enterobacter aerogenes strains [J].

Chevalier, J ;

Atifi, S ;

Eyraud, A ;

Mahamoud, A ;

Barbe, J ;

Pagès, JM .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (23) :4023-4026

[10]

Chung Y J, 2001, Curr Opin Drug Discov Devel, V4, P237

← 1 2 3 4 5 6 7 8 9 10 →