Immunosuppressive Drugs and Tregs: A Critical Evaluation!

被引：58

作者：

De Serres, Sacha A.

Sayegh, Mohamed H.

Najafian, Nader ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Div Renal, Transplantat Res Ctr, Boston, MA 02115 USA

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2009年 / 4卷 / 10期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; CLINICAL TRANSPLANTATION TOLERANCE; TRANSCRIPTION FACTOR FOXP3; KIDNEY ALLOGRAFT PATIENTS; CALCINEURIN INHIBITORS; CUTTING EDGE; TGF-BETA; IN-VITRO; LYMPHOCYTE SUBPOPULATIONS;

D O I：

10.2215/CJN.03180509

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To define therapeutic strategies that promote tolerance, it is of critical importance to determine the effects of immunosuppressive drugs on regulatory T cells (Tregs). This review discusses the current knowledge about the physiology of Tregs in humans, the role or Tregs in transplantation, and the impact of the different types of immunosuppressive agents on the frequency and functionality of Tregs in in vitro and in vivo systems. Clin J Am Soc Nephrol 4: 1661-1669, 2009. doi: 10.2215/CJN.03180509

引用

页码：1661 / 1669

页数：9

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