Point mutations of the BCL-6 gene in Burkitt's lymphoma

被引：27

作者：

Capello, D

Carbone, A

Pastore, C

Gloghini, A

Saglio, G

Gaidano, G

机构：

[1] UNIV TURIN,DEPT MED SCI,DIV INTERNAL MED,I-28100 NOVARA,ITALY

[2] UNIV TURIN,DEPT BIOMED SCI & HUMAN ONCOL,LAB MED & ONCOL MOL,ORBASSANO,ITALY

[3] INRCCS,CTR RIFERIMENTO ONCOL,DIV PATHOL,AVIANO,ITALY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 99卷 / 01期

关键词：

BCL-6; genetic lesion; Burkitt's lymphoma; AIDS; germinal centre;

D O I：

10.1046/j.1365-2141.1997.3573171.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BCL-6 codes for a transcription factor implicated in chromosomal translocations of diffuse large cell lymphomas. Recent evidence indicates that BCL-6 may also be altered by mutations of its 5' non-coding regions. In this study we have investigated the distribution of BCL-6 5' mutations among 35 Burkitt's lymphoma cases representative of the epidemiologic variants of the disease. Mutations were detected in 6/21 (28.6%) sporadic Burkitt's lymphomas and 7/14 (50%) endemic Burkitt's lymphomas. These data expand the spectrum of B-cell non-Hodgkin's lymphomas associated with BCL-6 5' mutations and have implications for the pathogenesis, histogenesis and clinical monitoring of Burkitt's lymphoma.

引用

页码：168 / 170

页数：3