VAV proteins as signal integrators for multi-subunit immune-recognition receptors

被引：268

作者：

Turner, M ^{[1
]}

Billadeau, DD

机构：

[1] Babraham Inst, Lymphocyte Signalling & Dev Lab, Mol Immunol Programme, Cambridge CB2 4AT, England

[2] Mayo Clin & Mayo Fdn, Div Dev Oncol Res, Rochester, MN 55905 USA

[3] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 07期

关键词：

D O I：

10.1038/nri840

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.

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收藏

页码：476 / 486

页数：11

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