VAV proteins as signal integrators for multi-subunit immune-recognition receptors

被引：268

作者：

Turner, M ^{[1
]}

Billadeau, DD

机构：

[1] Babraham Inst, Lymphocyte Signalling & Dev Lab, Mol Immunol Programme, Cambridge CB2 4AT, England

[2] Mayo Clin & Mayo Fdn, Div Dev Oncol Res, Rochester, MN 55905 USA

[3] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 07期

关键词：

D O I：

10.1038/nri840

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, substantial progress has been made towards the identification of intracellular signalling molecules that couple multi-subunit immune-recognition receptors (MIRRs) to their various effector functions. Among these, the VAV proteins have been observed to have a crucial role in regulating some of the earliest events in receptor signalling. VAV proteins function, in part, as guanine-nucleotide exchange factors (GEFs) for the RHO/RAC family of GTPases. This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms.

引用

收藏

页码：476 / 486

页数：11

相关论文

共 123 条

[51] Role of substrates and products of PI3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav [J].

Han, JW ;

Luby-Phelps, K ;

Das, B ;

Shu, XD ;

Xia, Y ;

Mosteller, RD ;

Krishna, UM ;

Falck, JR ;

White, MA ;

Broek, D .

SCIENCE, 1998, 279 (5350) :558-560

[52] Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription [J].

Hehner, SP ;

Hofmann, TG ;

Dienz, O ;

Dröge, W ;

Schmitz, ML .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (24) :18160-18171

[53] Small GTPases in lymphocyte biology -: Rho proteins take center stage [J].

Henning, S ;

Cleverley, S .

IMMUNOLOGIC RESEARCH, 1999, 20 (01) :29-42

[54] Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction [J].

Holsinger, LJ ;

Graef, IA ;

Swat, W ;

Chi, T ;

Bautista, DM ;

Davidson, L ;

Lewis, RS ;

Alt, FW ;

Crabtree, GR .

CURRENT BIOLOGY, 1998, 8 (10) :563-572

[55] T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase [J].

Huang, JY ;

Tilly, D ;

Altman, A ;

Sugie, K ;

Grey, HM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (20) :10923-10929

[56] Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation [J].

Inabe, K ;

Ishiai, M ;

Scharenberg, AM ;

Freshney, N ;

Downward, J ;

Kurosaki, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (02) :189-200

[57] Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast [J].

Isakoff, SJ ;

Cardozo, T ;

Andreev, J ;

Li, Z ;

Ferguson, KM ;

Abagyan, R ;

Lemmon, MA ;

Aronheim, A ;

Skolnik, EY .

EMBO JOURNAL, 1998, 17 (18) :5374-5387

[58] Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells [J].

Jiang, K ;

Zhong, B ;

Gilvary, DL ;

Corliss, BC ;

Hong-Geller, E ;

Wei, S ;

Djeu, JY .

NATURE IMMUNOLOGY, 2000, 1 (05) :419-425

[59] Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter [J].

Kaminuma, O ;

Deckert, M ;

Elly, C ;

Liu, YC ;

Altman, A .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (09) :3126-3136

[60] LOSS OF THE AMINO-TERMINAL HELIX-LOOP-HELIX DOMAIN OF THE VAV PROTOONCOGENE ACTIVATES ITS TRANSFORMING POTENTIAL [J].

KATZAV, S ;

CLEVELAND, JL ;

HESLOP, HE ;

PULIDO, D .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (04) :1912-1920

← 1 2 3 4 5 6 7 8 9 10 →