The molecular diversity of glycosaminoglycans shapes animal development

被引：259

作者：

Bulow, Hannes E. ^{[1
]}

Hobert, Oliver

机构：

[1] Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA

[2] Columbia Univ, Med Ctr, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2006年 / 22卷

关键词：

proteoglycans; heparan sulfate; chondroitin sulfate; dermatan sulfate; keratan sulfate; axon patterning;

D O I：

10.1146/annurev.cellbio.22.010605.093433

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked to a protein core, are components of the extracellular matrix of all multicellular organisms. Sugar moieties in GAGs are often extensively modified, which make these molecules enormously complex. We discuss here the role of PGs during animal development, emphasizing the in vivo significance of sugar modifications. We explore a model in which the modification patterns of GAG chains may provide a specific code that contributes to the correct development of a multicellular organism.

引用

页码：375 / 407

页数：33

共 165 条

[1] The NC1/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance [J].

Ackley, BD ;

Crew, JR ;

Elamaa, H ;

Pihlajaniemi, T ;

Kuo, CJ ;

Kramer, JM .

JOURNAL OF CELL BIOLOGY, 2001, 152 (06) :1219-1232

[2] CLONING OF THE PUTATIVE TUMOR-SUPPRESSOR GENE FOR HEREDITARY MULTIPLE EXOSTOSES (EXT1) [J].

AHN, J ;

JOSEFLUDECKE, H ;

LINDOW, S ;

HORTON, WA ;

LEE, B ;

WAGNER, MJ ;

HORSTHEMKE, B ;

WELLS, DE .

NATURE GENETICS, 1995, 11 (02) :137-143

[3] Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene [J].

Akama, TO ;

Nishida, K ;

Nakayama, J ;

Watanabe, H ;

Ozaki, K ;

Nakamura, T ;

Dota, A ;

Kawasaki, S ;

Inoue, Y ;

Maeda, N ;

Yamamoto, S ;

Fujiwara, T ;

Thonar, EJMA ;

Shimomura, Y ;

Kinoshita, S ;

Tanigami, A ;

Fukuda, MN .

NATURE GENETICS, 2000, 26 (02) :237-241

[4]

ALEXANDRATOU E, 2000, P SOC PHOTO-OPT INS, V1, P25

[5] Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly [J].

Allen, BL ;

Rapraeger, AC .

JOURNAL OF CELL BIOLOGY, 2003, 163 (03) :637-648

[6] Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice [J].

Arikawa-Hirasawa, E ;

Rossi, SG ;

Rotundo, RL ;

Yamada, Y .

NATURE NEUROSCIENCE, 2002, 5 (02) :119-123

[7] Perlecan is essential for cartilage and cephalic development [J].

Arikawa-Hirasawa, E ;

Watanabe, H ;

Takami, H ;

Hassell, JR ;

Yamada, Y .

NATURE GENETICS, 1999, 23 (03) :354-358

[8]

Baeg GH, 2001, DEVELOPMENT, V128, P87

[9] Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness [J].

Bech-Hansen, NT ;

Naylor, MJ ;

Maybaum, TA ;

Sparkes, RL ;

Koop, B ;

Birch, DG ;

Bergen, AAB ;

Prinsen, CFM ;

Polomeno, RC ;

Gal, A ;

Drack, AV ;

Musarella, MA ;

Jacobson, SG ;

Young, RSL ;

Weleber, RG .

NATURE GENETICS, 2000, 26 (03) :319-323

[10] Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion [J].

Bellaiche, Y ;

The, I ;

Perrimon, N .

NATURE, 1998, 394 (6688) :85-88

← 1 2 3 4 5 6 7 8 9 10 →