The molecular diversity of glycosaminoglycans shapes animal development

被引：259

作者：

Bulow, Hannes E. ^{[1
]}

Hobert, Oliver

机构：

[1] Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA

[2] Columbia Univ, Med Ctr, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2006年 / 22卷

关键词：

proteoglycans; heparan sulfate; chondroitin sulfate; dermatan sulfate; keratan sulfate; axon patterning;

D O I：

10.1146/annurev.cellbio.22.010605.093433

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked to a protein core, are components of the extracellular matrix of all multicellular organisms. Sugar moieties in GAGs are often extensively modified, which make these molecules enormously complex. We discuss here the role of PGs during animal development, emphasizing the in vivo significance of sugar modifications. We explore a model in which the modification patterns of GAG chains may provide a specific code that contributes to the correct development of a multicellular organism.

引用

页码：375 / 407

页数：33

共 165 条

[71] Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans [J].

Kantor, DB ;

Chivatakarn, O ;

Peer, KL ;

Oster, SF ;

Inatani, M ;

Hansen, MJ ;

Flanagan, JG ;

Yamaguchi, Y ;

Sretavan, DW ;

Giger, RJ ;

Kolodkin, AL .

NEURON, 2004, 44 (06) :961-975

[72] Physiological regulation of the immunological synapse by agrin [J].

Khan, AA ;

Bose, C ;

Yam, LS ;

Soloski, MJ ;

Rupp, F .

SCIENCE, 2001, 292 (5522) :1681-1686

[73] Myelination and behaviour of tenascin-C null transgenic mice [J].

Kiernan, BW ;

Garcion, E ;

Ferguson, J ;

Frost, EE ;

Torres, EM ;

Dunnett, SB ;

Saga, Y ;

Aizawa, S ;

Faissner, A ;

Kaur, R ;

Franklin, RJM ;

ffrench-Constant, C .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (09) :3082-3092

[74] Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans [J].

Kinnunen, T ;

Huang, ZB ;

Townsend, J ;

Gatdula, MM ;

Brown, JR ;

Esko, JD ;

Turnbull, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (05) :1507-1512

[75] Spatial regulation of wingless morphogen distribution and signaling by dally-like protein [J].

Kirkpatrick, CA ;

Dimitroff, BD ;

Rawson, JM ;

Selleck, SB .

DEVELOPMENTAL CELL, 2004, 7 (04) :513-523

[76] An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis [J].

Kizawa, H ;

Kou, I ;

Iida, A ;

Sudo, A ;

Miyamoto, Y ;

Fukuda, A ;

Mabuchi, A ;

Kotani, A ;

Kawakami, A ;

Yamamoto, S ;

Uchida, A ;

Nakamura, K ;

Notoya, K ;

Nakamura, Y ;

Ikegawa, S .

NATURE GENETICS, 2005, 37 (02) :138-144

[77] Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis [J].

Klüppel, M ;

Wight, TN ;

Chan, C ;

Hinek, A ;

Wrana, JL .

DEVELOPMENT, 2005, 132 (17) :3989-4003

[78] Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor [J].

Kramer, KL ;

Yost, HJ .

DEVELOPMENTAL CELL, 2002, 2 (01) :115-124

[79] Heparin sulfate core proteins in cell-cell signaling [J].

Kramer, KL ;

Yost, HJ .

ANNUAL REVIEW OF GENETICS, 2003, 37 :461-484

[80] Opposing activities of dally-like glypican at high and low levels of wingless morphogen activity [J].

Kreuger, J ;

Perez, L ;

Giraldez, AJ ;

Cohen, SM .

DEVELOPMENTAL CELL, 2004, 7 (04) :503-512

← 3 4 5 6 7 8 9 10 11 12 →