The molecular diversity of glycosaminoglycans shapes animal development

被引：259

作者：

Bulow, Hannes E. ^{[1
]}

Hobert, Oliver

机构：

[1] Albert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA

[2] Columbia Univ, Med Ctr, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2006年 / 22卷

关键词：

proteoglycans; heparan sulfate; chondroitin sulfate; dermatan sulfate; keratan sulfate; axon patterning;

D O I：

10.1146/annurev.cellbio.22.010605.093433

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteoglycans (PGs), molecules in which glycosaminoglycans (GAGs) are covalently linked to a protein core, are components of the extracellular matrix of all multicellular organisms. Sugar moieties in GAGs are often extensively modified, which make these molecules enormously complex. We discuss here the role of PGs during animal development, emphasizing the in vivo significance of sugar modifications. We explore a model in which the modification patterns of GAG chains may provide a specific code that contributes to the correct development of a multicellular organism.

引用

页码：375 / 407

页数：33

共 165 条

[51] A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions [J].

Harroch, S ;

Furtado, GC ;

Brueck, W ;

Rosenbluth, J ;

Lafaille, J ;

Chao, M ;

Buxbaum, JD ;

Schlessinger, J .

NATURE GENETICS, 2002, 32 (03) :411-414

[52] sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination [J].

Herman, T ;

Hartwieg, E ;

Horvitz, HR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (03) :968-973

[53] Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway [J].

Herman, T ;

Horvitz, HR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (03) :974-979

[54] Development and maintenance of neuronal architecture at the ventral midline of C-elegans [J].

Hobert, O ;

Bülow, H .

CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (01) :70-78

[55] Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein [J].

Hu, HY .

NATURE NEUROSCIENCE, 2001, 4 (07) :695-701

[56] Heparin is essential for the storage of specific granule proteases in mast cells [J].

Humphries, DE ;

Wong, GW ;

Friend, DS ;

Gurish, MF ;

Qiu, WT ;

Huang, CF ;

Sharpe, AH ;

Stevens, RL .

NATURE, 1999, 400 (6746) :769-772

[57] Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis [J].

Hwang, HY ;

Olson, SK ;

Esko, JD ;

Horvitz, HR .

NATURE, 2003, 423 (6938) :439-443

[58] The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase [J].

Hwang, HY ;

Olson, SK ;

Brown, JR ;

Esko, JD ;

Horvitz, HR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (14) :11735-11738

[59] The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development [J].

Hwang, HY ;

Horvitz, HR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) :14218-14223

[60] Mammalian brain morphogenesis and midline axon guidance require heparan sulfate [J].

Inatani, M ;

Irie, F ;

Plump, AS ;

Tessier-Lavigne, M ;

Yamaguchi, Y .

SCIENCE, 2003, 302 (5647) :1044-1046

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