Azide Conjugatable and pH Responsive Near-Infrared Fluorescent Imaging Probes

被引：175

作者：

Murtagh, Julie ^{[1
]}

Frimannsson, Daniel O. ^{[1
]}

O'Shea, Donal F. ^{[1
]}

机构：

[1] Univ Coll Dublin, Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 23期

基金：

爱尔兰科学基金会;

关键词：

IN-VIVO; PHOTODYNAMIC THERAPY; LABELED ENDOSTATIN; SINGLE; TETRAARYLAZADIPYRROMETHENES; LOCALIZATION; CHEMOSENSOR; DISCOVERY; PLATFORM; AGENTS;

D O I：

10.1021/ol902140v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and photophysical characteristics of a pH responsive near-infrared fluorescence imaging probe is described. A key feature is the ability to conjugate the probe by an alkyne-azide cycloaddition reaction and its reversible response of fluorescence intensity across the physiological pH range.

引用

页码：5386 / 5389

页数：4

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