Epstein-Barr virus in the pathogenesis of NPC

被引:428
作者
Raab-Traub, N [1 ]
机构
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
关键词
Epstein-Barrvirus; nasopharyngeal carcinoma; Hodgkin's disease; latent membrane proteins 1 and 2;
D O I
10.1016/S1044579X0200086X
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Epstein-Barr virus (EBV) is consistently detected in nasopharyngeal carcinoma (NPC) from regions of high and low incidence. EBV DNA within the tumor is homogeneous with regard to the number of terminal repeats. The detection Of a single form of viral DNA suggests that the tumors are clonal proliferations of a single cell that was initially infected with EBV Specific EBV genes are consistently expressed within the NPC tumors and in early, dysplastic lesions. The viral proteins, latent membrane protein I and 2, have Profound effects on cellular gene expression and cellular growth, resulting in the highly invasive, malignant growth of NPC tumors. In addition to potential genetic changes, the establishment of a latent, transforming infection in epithelial cells is likely to be a major contributing factor to the development of this tumor.
引用
收藏
页码:431 / 441
页数:11
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