Improved synthesis of (±)-4,12-dihydroxy[2.2]paracyclophane and its enantiomeric resolution by enzymatic methods:: Planar chiral (R)- and (S)-phanol

被引：65

作者：

Braddock, DC ^{[1
]}

MacGilp, LD

Perry, BG

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[2] GlaxoSmithKline Res & Dev Ltd, Proc Chem, Dartford DA1 5AH, Kent, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 24期

关键词：

D O I：

10.1021/jo020451x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+/-)-4,12-Dihydroxy[2.2]paracyclophane [(+/-)PHANOL] is readily prepared from [2.2]paracyclophane by an improved synthetic protocol. Enzymatic kinetic resolution of its bis-acetate proceeds with good enantioselection. Separation, hydrolysis, and recrystallization provides both enantiomers of PHANOL in high enantiopurity.

引用

页码：8679 / 8681

页数：3

共 40 条

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