Highly efficient kinetic resolution of 2-cyclohexenyl acetate in Pd-catalyzed allylic alkylation

被引：82

作者：

Longmire, JM ^{[1
]}

Wang, B ^{[1
]}

Zhang, XM ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 29期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)00844-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new phosphine ligand has been synthesized and employed in the Pd-catalyzed alkylation of 2-cyclohexenyl esters. A very efficient resolution of 2-cyclohexenyl acetate was observed during alkylation. In addition, the reactivity and enantioselectivity showed a strong dependence on the acetate salt with the BSA/MOAc (M = alkali metal) base system during alkyation of cyclohexenyl carbonate. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：5435 / 5439

页数：5

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