ENANTIOMERICALLY PURE CYCLOALKENYLACETIC-ACID DERIVATIVES VIA PD-CATALYZED ASYMMETRIC ALLYLIC ALKYLATION AND SUBSEQUENT ENANTIOMERIC ENRICHMENT VIA IODOLACTONES

被引：92

作者：

SENNHENN, P ^{[1
]}

GABLER, B ^{[1
]}

HELMCHEN, G ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST ORGAN CHEM,D-69120 HEIDELBERG,GERMANY

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(00)78445-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral (phosphinoaryl-oxazoline)Pd complexes with stereogenic phosphorus were used as catalysts for alkylation of cycloalkenyl acetates which gave products with up to 85% ee. Excellent reactivity allowed reactions with as little as 0.02 mol% of Pd. Five- and six-membered ring synthons of interest for syntheses of biologically active compounds with > 99% ee were obtained via recrystallization of iodolactones.

引用

页码：8595 / 8598

页数：4

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