Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: A new positron emission tomography ligand for nicotinic receptors

被引：57

作者：

Liang, F

Navarro, HA

Abraham, P

Kotian, P

Ding, YS

Fowler, J

Volkow, N

Kuhar, MJ

Carroll, FI

机构：

[1] RES TRIANGLE INST,RES TRIANGLE PK,NC 27709

[2] BROOKHAVEN NATL LAB,UPTON,NY 11973

[3] NIDA,ADDICT RES CTR,BALTIMORE,MD 21224

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 40卷 / 15期

关键词：

D O I：

10.1021/jm970187d

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：2293 / 2295

页数：3

共 28 条

[21]

OKABE K, 1994, CHEM PHARM BULL, V42, P1432

[22] In vivo labeling of neuronal nicotinic acetylcholine receptors with radiolabeled isomers of norchloroepibatidine [J].

Scheffel, U ;

Taylor, GF ;

Kepler, JA ;

Carroll, FI ;

Kuhar, MJ .

NEUROREPORT, 1995, 6 (18) :2483-2488

[23]

SENOKUCHI K, 1994, SYNLETT, V34, P344

[24] SYNTHESIS OF EPIBATIDINE [J].

SESTANJ, K ;

MELENSKI, E ;

JIRKOVSKY, I .

TETRAHEDRON LETTERS, 1994, 35 (30) :5417-5420

[25] EPIBATIDINE - A NOVEL (CHLOROPYRIDYL)AZABICYCLOHEPTANE WITH POTENT ANALGESIC ACTIVITY FROM AN ECUADORIAN POISON FROG [J].

SPANDE, TF ;

GARRAFFO, HM ;

EDWARDS, MW ;

YEH, HJC ;

PANNELL, L ;

DALY, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (09) :3475-3478

[26]

SULLIVAN JP, 1996, CNS DRUG REV, V2, P21

[27] A PRACTICAL ROUTE TO EPIBATIDINE [J].

SZANTAY, C ;

KARDOSBALOGH, Z ;

MOLDVAI, I ;

SZANTAY, C ;

TEMESVARIMAJOR, E ;

BLASKO, G .

TETRAHEDRON LETTERS, 1994, 35 (19) :3171-3174

[28]

Villemagne V. L., 1996, Journal of Nuclear Medicine, V37, p11P

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