Transmitter receptors and functional anatomy of the cerebral cortex

被引:115
作者
Zilles, K
Palomero-Gallagher, N
Schleicher, A
机构
[1] Forschungszentrum Julich, Inst Med, D-52425 Julich, Germany
[2] Univ Dusseldorf, C&O Vogt Inst Brain Res, D-4000 Dusseldorf, Germany
关键词
brain mapping; cortical organization; human brain; receptor autoradiography; transmitter receptor;
D O I
10.1111/j.0021-8782.2004.00357.x
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
The currently available architectonic maps of the human cerebral cortex do not match the high degree of cortical segregation as shown by functional imaging. Such functional imaging studies have demonstrated a considerable number of functionally specialized areas not displayed in the architectonic maps. We therefore analysed the regional and laminar distribution of various transmitter receptors in the human cerebral cortex, because these signalling molecules play a crucial role in cortical functions. They may provide a novel and functionally more relevant insight into the regional organization of the cortex, which cannot be achieved by architectonic observations in cell body- or myelin-stained sections. Serial cryostat sections through whole human hemispheres were used for quantitative receptor autoradiography. The regional and laminar densities of numerous receptors of classic transmitter systems were analysed. Alternating sections were stained for comparisons based on cyto- or myeloarchitectonic criteria. Our results demonstrate that the regional distribution of transmitter receptors reflects well-established cyto- and myeloarchitectonically defined borders of cortical areas, but in addition enables the identification of more cortical areas than previously demonstrated. Moreover, the laminar distribution patterns of a given receptor type in different cortical areas as well as those of different receptor types in the same cortical area reveal novel and functionally relevant data concerning the intracortical organization in the human cerebral cortex.
引用
收藏
页码:417 / 432
页数:16
相关论文
共 90 条
[21]   EVIDENCE FOR A CHOLINERGIC MECHANISM OF LEARNED CHANGES IN THE RESPONSES OF BARREL FIELD NEURONS OF THE AWAKE AND UNDRUGGED RAT [J].
DELACOUR, J ;
HOUCINE, O ;
COSTA, JC .
NEUROSCIENCE, 1990, 34 (01) :1-8
[22]  
Douglas CL, 2001, J PHARMACOL EXP THER, V299, P960
[23]   Ventral intraparietal area of the macaque: Congruent visual and somatic response properties [J].
Duhamel, JR ;
Colby, CL ;
Goldberg, ME .
JOURNAL OF NEUROPHYSIOLOGY, 1998, 79 (01) :126-136
[24]  
FISCHER A, 1987, J DANISH ARCHAEOLOGY, V5, P7
[25]   The brain basis of syntactic processes: functional imaging and lesion studies [J].
Friederici, AD ;
Kotz, SA .
NEUROIMAGE, 2003, 20 :S8-S17
[26]   Areas 3a, 3b, and 1 of human primary somatosensory cortex - 2. Spatial normalization to standard anatomical space [J].
Geyer, S ;
Schormann, T ;
Mohlerg, H ;
Zilles, K .
NEUROIMAGE, 2000, 11 (06) :684-696
[27]   Areas 3a, 3b, and 1 of human primary somatosensory cortex 1. Microstructural organization and interindividual variability [J].
Geyer, S ;
Schleicher, A ;
Zilles, K .
NEUROIMAGE, 1999, 10 (01) :63-83
[28]   Two different areas within the primary motor cortex of man [J].
Geyer, S ;
Ledberg, A ;
Schleicher, A ;
Kinomura, S ;
Schormann, T ;
Burgel, U ;
Klingberg, T ;
Larsson, J ;
Zilles, K ;
Roland, PE .
NATURE, 1996, 382 (6594) :805-807
[29]   The somatosensory cortex of human: Cytoarchitecture and regional distributions of receptor-binding sites [J].
Geyer, S ;
Schleicher, A ;
Zilles, K .
NEUROIMAGE, 1997, 6 (01) :27-45
[30]   Human somatosensory area 2: Observer-independent cytoarchitectonic mapping, interindividual variability, and population map [J].
Grefkes, C ;
Geyer, S ;
Schormann, T ;
Roland, P ;
Zilles, K .
NEUROIMAGE, 2001, 14 (03) :617-631