Glutamate-mediated transmission, alcohol, and alcoholism

被引:144
作者
Dodd, PR [1 ]
Beckmann, AM [1 ]
Davidson, MS [1 ]
Wilce, PA [1 ]
机构
[1] Univ Queensland, Dept Biochem, Brisbane, Qld 4072, Australia
关键词
ethanol; pathogenesis; dependency; excitatory amino acid; receptors-subunits; treatment of dependency; drug mechanisms; review;
D O I
10.1016/S0197-0186(00)00061-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glutamate-mediated neurotransmission may be involved in the range of adaptive changes in brain which occur after ethanol administration in laboratory animals, and in chronic alcoholism in human cases. Excitatory amino acid transmission is modulated by a complex system of receptors and other effecters, the efficacy of which can be profoundly affected by altered gene or protein expression. Local variations in receptor composition may underlie intrinsic regional variations in susceptibility to pathological change. Equally, ethanol use and abuse may bring about alterations in receptor subunit expression as the essence of the adaptive response. Such considerations may underlie the regional localization characteristic of the pathogenesis of alcoholic brain damage, or they may form part of the homeostatic change that constitutes the neural substrate for alcohol dependence. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:509 / 533
页数:25
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