Lack of association between toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus

被引：70

作者：

Moore, CE

Segal, S

Berendt, AR

Hill, AVS

Day, NPJ

机构：

[1] Mahidol Univ, Fac Trop Med, Bangkok, Thailand

[2] Nuffield Orthopaed Ctr, Bone Infect Unit, NHS Trust, Oxford OX3 7LD, England

[3] John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2004年 / 11卷 / 06期

关键词：

D O I：

10.1128/CDLI.11.6.1194-1197.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

引用

页码：1194 / 1197

页数：4

共 13 条

[11] Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses [J].