A system biology perspective on environment-host-microbe interactions

被引：39

作者：

Chen, Lianmin ^{[1
,2
]}

Garmaeva, Sanzhima ^{[1
]}

Zhernakova, Alexandra ^{[1
]}

Fu, Jingyuan ^{[1
,2
]}

Wijmenga, Cisca ^{[1
,3
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, NL-9700 RB Groningen, Netherlands

[3] Univ Oslo, KG Jebsen Coeliac Dis Res Ctr, Dept Immunol, N-0318 Oslo, Norway

来源：

HUMAN MOLECULAR GENETICS | 2018年 / 27卷 / R2期

基金：

欧洲研究理事会;

关键词：

INFLAMMATORY-BOWEL-DISEASE; HUMAN GUT MICROBIOTA; EARLY-LIFE; GENETICS; BACTERIA; OBESITY; DIET; METAGENOMICS; ASSOCIATION; RECEPTOR;

D O I：

10.1093/hmg/ddy137

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A vast, complex and dynamic consortium of microorganisms known as the gut microbiome colonizes the human gut. Over the past few decades, we have developed an increased awareness of its important role in human health. In this review we discuss the role of the gut microbiome in complex diseases and the possible causal scenarios behind its interactions with the host genome and environmental factors. We then propose a new analysis framework that combines a systems biology approach, cross-kingdom integration of multiple levels of omics data, and innovative in vitro models to yield an integrated picture of human host-microbe interactions. This new framework will lay the foundation for the development of the next phase in personalized medicine.

引用

页码：R187 / R194

页数：8

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