Population-level analysis of gut microbiome variation

被引：1635

作者：

Falony, Gwen ^{[1
,2
]}

Joossens, Marie ^{[1
,2
,3
]}

Vieira-Silva, Sara ^{[1
,2
]}

Wang, Jun ^{[1
,2
]}

Darzi, Youssef ^{[1
,2
,3
]}

Faust, Karoline ^{[1
,2
,3
]}

Kurilshikov, Alexander ^{[4
,5
]}

Bonder, Marc Jan ^{[6
]}

Valles-Colomer, Mireia ^{[1
,2
]}

Vandeputte, Doris ^{[1
,2
,3
]}

Tito, Raul Y. ^{[1
,2
,3
]}

Chaffron, Samuel ^{[1
,2
,3
]}

Rymenans, Leen ^{[1
,2
,3
]}

Verspecht, Chlo ^{[1
,2
]}

De Sutter, Lise ^{[1
,2
,3
]}

Lima-Mendez, Gipsi ^{[1
,2
]}

D'hoe, Kevin ^{[1
,2
,3
]}

Jonckheere, Karl ^{[2
,3
]}

Homola, Daniel ^{[2
,3
]}

Garcia, Roberto ^{[2
,3
]}

Tigchelaar, Ettje F. ^{[6
,7
]}

Eeckhaudt, Linda ^{[2
,3
]}

Fu, Jingyuan ^{[6
,8
]}

Henckaerts, Liesbet ^{[1
,9
]}

Zhernakova, Alexandra ^{[6
,7
]}

Wijmenga, Cisca ^{[6
]}

Raes, Jeroen ^{[1
,2
,3
]}

机构：

[1] Univ Leuven, Dept Microbiol & Immunol, KU Leuven, Leuven, Belgium

[2] VIB, Ctr Biol Dis, Leuven, Belgium

[3] Vrije Univ Brussel, Fac Sci & Bioengn Sci, Microbiol Unit, Brussels, Belgium

[4] Inst Chem Biol & Fundamental Med SB RAS, Novosibirsk, Russia

[5] Novosibirsk State Univ, Novosibirsk 630090, Russia

[6] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

[7] Top Inst Food & Nutr, Wageningen, Netherlands

[8] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, NL-9700 RB Groningen, Netherlands

[9] Univ Hosp Leuven, Dept Gen Internal Med, KU Leuven, Leuven, Belgium

来源：

SCIENCE | 2016年 / 352卷 / 6285期

关键词：

FAECALIBACTERIUM-PRAUSNITZII; INTESTINAL MICROBIOTA; ENTEROTYPES; ACQUISITION; METAGENOME; DIVERSITY; RICHNESS; HEALTH; IMPACT; RISK;

D O I：

10.1126/science.aad3503

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnaire-based covariates were found associated to microbiota compositional variation with a 92% replication rate. Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations. Early-life events such as birth mode were not reflected in adult microbiota composition. Finally, we found that proposed disease marker genera associated to host covariates, urging inclusion of the latter in study design.

引用

页码：560 / 564

页数：5

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