Artemisinin resistance: current status and scenarios for containment

被引：487

作者：

Dondorp, Arjen M. ^{[1
,2
]}

Yeung, Shunmay ^{[1
,3
]}

White, Lisa ^{[1
,2
]}

Nguon, Chea ^{[3
]}

Day, Nicholas P. J. ^{[1
,2
]}

Socheat, Duong ^{[3
,4
]}

von Seidlein, Lorenz ^{[1
,5
]}

机构：

[1] Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok 10400, Thailand

[2] Univ Oxford, Churchill Hosp, Ctr Trop Med, Oxford OX3 7LJ, England

[3] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

[4] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia

[5] Joint Malaria Project, Tanga, Tanzania

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 04期

基金：

英国惠康基金;

关键词：

UNCOMPLICATED FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; ARTESUNATE-MEFLOQUINE; COMBINATION THERAPY; DRUG-RESISTANCE; ARTEMETHER-LUMEFANTRINE; CHLOROQUINE RESISTANCE; ANTIMALARIAL EFFICACY; CYTOCHROME-B; IN-VITRO;

D O I：

10.1038/nrmicro2331

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodia-Thailand border. Exposure of the parasite population to artemisinin monotherapies in subtherapeutic doses for over 30 years, and the availability of substandard artemisinins, have probably been the main driving force in the selection of the resistant phenotype in the region. A multifaceted containment programme has recently been launched, including early diagnosis and appropriate treatment, decreasing drug pressure, optimising vector control, targeting the mobile population, strengthening management and surveillance systems, and operational research. Mathematical modelling can be a useful tool to evaluate possible strategies for containment.

引用

页码：272 / 280

页数：9

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