Uniform Beads with Controllable Pore Sizes for Biomedical Applications

被引：71

作者：

Choi, Sung-Wook ^{[1
]}

Yeh, Yi-Chun ^{[1
,2
]}

Zhang, Yu ^{[1
]}

Sung, Hsing-Wen ^{[2
]}

Xia, Younan ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu, Taiwan

来源：

SMALL | 2010年 / 6卷 / 14期

关键词：

biomedicine; cells; emulsions; phase separation; porous beads; IN-VITRO; HEPATOCYTE SPHEROIDS; MASS-TRANSFER; TISSUE; MICROSPHERES; MICROCARRIERS; COMPOSITE; CARTILAGE; CARRIERS; SCAFFOLD;

D O I：

10.1002/smll.201000544

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Uniform beads of poly(D,L-lactide-co- glycolide) with small or large pores are fabricated by selectively introducing phase-separated layers of an unstable emulsion into a fluidic device using a syringe with a tip offset from the barrel. When fibroblasts are cultured in the beads, a higher density of viable cells occurs in the beads with larger pores. These beads could be useful for tissue engineering and cell-delivery applications.

引用

页码：1492 / 1498

页数：7

共 32 条

[1] Angiogenesis in cancer and other diseases [J].

Carmeliet, P ;

Jain, RK .

NATURE, 2000, 407 (6801) :249-257

[2] Preparation of Uniform Microspheres Using a Simple Fluidic Device and Their Crystallization into Close-Packed Lattices [J].

Choi, Sung-Wook ;

Cheong, In Woo ;

Kim, Jung-Hyun ;

Xia, Younan .

SMALL, 2009, 5 (04) :454-459

[3] Highly open porous biodegradable microcarriers:: In vitro cultivation of chondrocytes for injectable delivery [J].

Chung, Hyun Jung ;

Kim, In Kyoung ;

Kim, Taek Gyoung ;

Park, Tae Gwan .

TISSUE ENGINEERING PART A, 2008, 14 (05) :607-615

[4] Injectable Cellular Aggregates Prepared from Biodegradable Porous Microspheres for Adipose Tissue Engineering [J].

Chung, Hyun Jung ;

Park, Tae Gwan .

TISSUE ENGINEERING PART A, 2009, 15 (06) :1391-1400

[5] HYDRODYNAMIC EFFECTS ON ANIMAL-CELLS GROWN IN MICROCARRIER CULTURES [J].

CROUGHAN, MS ;

HAMEL, JF ;

WANG, DIC .

BIOTECHNOLOGY AND BIOENGINEERING, 1987, 29 (01) :130-141

[6] Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system [J].

Curcio, Efrern ;

Salerno, Simona ;

Barbieri, Giuseppe ;

De Bartolo, Loredana ;

Drioli, Enrico ;

Bader, Augustinus .

BIOMATERIALS, 2007, 28 (36) :5487-5497

[7] Porous carriers for biomedical applications based on alginate hydrogels [J].

Eiselt, P ;

Yeh, J ;

Latvala, RK ;

Shea, LD ;

Mooney, DJ .

BIOMATERIALS, 2000, 21 (19) :1921-1927

[8] Engineered fetal cartilage: Structural and functional analysis in vitro [J].

Fuchs, JR ;

Terada, S ;

Hannouche, D ;

Ochoa, ER ;

Vacanti, JP ;

Fauza, DO .

JOURNAL OF PEDIATRIC SURGERY, 2002, 37 (12) :1720-1725

[9] Bone tissue engineering based on bead-cell sheets composed of calcium phosphate beads and bone marrow cells [J].

Furukawa, KS ;

Miyauchi, S ;

Suzuki, D ;

Umezu, Y ;

Shinjo, T ;

Ushida, T ;

Eguchi, M ;

Tateishi, T .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2004, 24 (03) :437-440

[10] Modeling mass transfer in hepatocyte spheroids via cell viability, spheroid size, and hepatocellular functions [J].

Glicklis, R ;

Merchuk, JC ;

Cohen, S .

BIOTECHNOLOGY AND BIOENGINEERING, 2004, 86 (06) :672-680

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