Lack of synergy of erythromycin combined with penicillin or cefotaxime against Streptococcus pneumoniae in vitro

被引：28

作者：

Lin, E ^{[1
]}

Stanek, RJ ^{[1
]}

Mufson, MA ^{[1
]}

机构：

[1] Marshall Univ, Sch Med, Dept Med, Huntington, WV 25701 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 03期

关键词：

D O I：

10.1128/AAC.47.3.1151-1153.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated a possible synergistic effect of a macrolide and beta-lactams against Streptococcus pneumoniae strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combinations in vitro act substantially as individuals in their activity against S. pneumoniae.

引用

页码：1151 / 1153

页数：3

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