Melotenine A, a Cytotoxic Monoterpenoid Indole Alkaloid from Melodinus tenuicaudatus

被引：77

作者：

Feng, Tao ^{[1
,2
]}

Li, Yan ^{[1
]}

Liu, Ya-Ping ^{[1
,2
]}

Cai, Xiang-Hai ^{[1
]}

Wang, Yuan-Yuan ^{[1
]}

Luo, Xiao-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ASPIDOSPERMA ALKALOIDS; REARRANGEMENT; CORE;

D O I：

10.1021/ol1000022

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Melotenine A (1), an unprecedented skeleton with a 6/5/5/6/7 pentacyclic rearranged ring system, was isolated from Melodinus tenuicaudatus. The structure was elucidated by means of spectroscopic methods and further confirmed by the single-crystal X-ray diffraction analysis. A possible biogenesis was also proposed. Melotenine A exhibited potential inhibition against five human cancer cell lines.

引用

收藏

页码：968 / 971

页数：4

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