Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice

被引：168

作者：

Helft, Julie ^{[1
,2
]}

Ginhoux, Florent ^{[1
,2
,3
]}

Bogunovic, Milena ^{[1
,2
]}

Merad, Miriam ^{[1
,2
]}

机构：

[1] Dept Gene & Cell Med, New York, NY USA

[2] Mt Sinai Sch Med, Inst Immunol, New York, NY USA

[3] ASTAR, Singapore Immunol Network SIgN, Biopolis, Singapore

来源：

IMMUNOLOGICAL REVIEWS | 2010年 / 234卷

基金：

美国国家卫生研究院;

关键词：

dendritic cells; CD103+dendritic cells; non-lymphoid tissue; homeostasis; functional specialization; COLONY-STIMULATING FACTOR; HEMATOPOIETIC PROGENITOR CELLS; INTERFERON-PRODUCING CELLS; REGULATORY T-CELLS; MHC CLASS-I; LANGERHANS CELLS; FLT3; LIGAND; STEADY-STATE; BONE-MARROW; EPITHELIAL-CELLS;

D O I：

10.1111/j.0105-2896.2009.00885.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Dendritic cells (DCs) have been extensively studied in mice lymphoid organs, but less is known about the origin and the mechanisms that regulate DC development and function in non-lymphoid tissues. Here, we discuss recent evidence establishing the contribution of the DC-restricted lineage to the non-lymphoid tissue DC pool and discuss the mechanisms that control the homeostasis of non-lymphoid tissue DCs. We also review recent results underlining the functional specialization of tissue DCs and discuss the potential implications of these findings in tissue immunity and in the development of novel vaccine strategies.

引用

页码：55 / 75

页数：21

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