E2F-6, a member of the E2F family that can behave as a transcriptional repressor

被引：192

作者：

Trimarchi, JM ^{[1
]}

Fairchild, B ^{[1
]}

Verona, R ^{[1
]}

Moberg, K ^{[1
]}

Andon, N ^{[1
]}

Lees, JA ^{[1
]}

机构：

[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 06期

关键词：

D O I：

10.1073/pnas.95.6.2850

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The E2F family of proteins is required to establish the correct cell-cycle-dependent transcription of genes that direct the process of cell division. All previously identified E2F proteins can act in a similar manner; depending on whether or not they are associated with the cell cycle inhibitors the retinoblastoma protein (pRB), p107, or p130, they can either repress or activate the transcription of E2F-responsive genes. We now report the cloning and characterization of another E2F family member, E2F-6, whose structure is reminiscent of the dominant inhibitors of other transcription factor families. The dimerization and DNA binding properties of E2F-6 are similar to those of the other E2F family members. However, it is not regulated by pRB, p107, or p130, and it is unable to activate transcription. Instead, it can act to repress the transcription of E2F responsive genes by countering the activity of the other E2F complexes via a pRB-, p107-, or p130-independent mechanism.

引用

页码：2850 / 2855

页数：6

共 38 条

[11]

DYSON N, 1992, CANCER SURV, V12, P161

[12] E2F-4, A NEW MEMBER OF THE E2F TRANSCRIPTION FACTOR FAMILY, INTERACTS WITH P107 [J].