Conserved noncoding sequences are reliable guides to regulatory elements

被引：336

作者：

Hardison, RC ^{[1
]}

机构：

[1] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

来源：

TRENDS IN GENETICS | 2000年 / 16卷 / 09期

关键词：

D O I：

10.1016/S0168-9525(00)02081-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A 'working draft' of the human genome sequence is now available. Comparisons with the sequences of mouse and other species will be a powerful approach to identifying functional segments of the noncoding regions, such as gene regulatory elements. However, the choice of a species for most effective comparison differs among various loci.

引用

页码：369 / 372

页数：4

共 22 条

[1] Ansari-Lari MA, 1998, GENOME RES, V8, P29
[2] DETECTING CONSERVED REGULATORY ELEMENTS WITH THE MODEL GENOME OF THE JAPANESE PUFFER FISH, FUGU RUBRIPES
APARICIO, S
MORRISON, A
GOULD, A
GILTHORPE, J
CHAUDHURI, C
RIGBY, P
KRUMLAUF, R
BRENNER, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) : 1684 - 1688
[3] An action plan for mouse genomics
Battey, J
Jordan, E
Cox, D
Dove, W
[J]. NATURE GENETICS, 1999, 21 (01) : 73 - 75
[4] Shotgun sample sequence comparisons between mouse and human genomes
Bouck, JB
Metzker, ML
Gibbs, RA
[J]. NATURE GENETICS, 2000, 25 (01) : 31 - 33
[5] Looping versus linking: toward a model for long-distance gene activation
Bulger, M
Groudine, M
[J]. GENES & DEVELOPMENT, 1999, 13 (19) : 2465 - 2477
[6] Computational methods for the identification of genes in vertebrate genomic sequences
Claverie, JM
[J]. HUMAN MOLECULAR GENETICS, 1997, 6 (10) : 1735 - 1744
[7] New goals for the US Human Genome Project: 1998-2003
Collins, FS
Patrinos, A
Jordan, E
Chakravarti, A
Gesteland, R
Walters, L
Fearon, E
Hartwelt, L
Langley, CH
Mathies, RA
Olson, M
Pawson, AJ
Pollard, T
Williamson, A
Wold, B
Buetow, K
Branscomb, E
Capecchi, M
Church, G
Garner, H
Gibbs, RA
Hawkins, T
Hodgson, K
Knotek, M
Meisler, M
Rubin, GM
Smith, LM
Smith, RF
Westerfield, M
Clayton, EW
Fisher, NL
Lerman, CE
McInerney, JD
Nebo, W
Press, N
Valle, D
[J]. SCIENCE, 1998, 282 (5389) : 682 - 689
[8] DUBCHAK I, IN PRESS GENOME RES
[9] Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes
Ellsworth, RE
Jamison, DC
Touchman, JW
Chissoe, SL
Maduro, VVB
Bouffard, GG
Dietrich, NL
Beckstrom-Sternberg, SM
Iyer, LM
Weintraub, LA
Cotton, M
Courtney, L
Edwards, J
Maupin, R
Ozersky, P
Rohlfing, T
Wohldmann, P
Miner, T
Kemp, K
Kramer, J
Korf, I
Pepin, K
Antonacci-Fulton, L
Fulton, RS
Minx, P
Hillier, LW
Wilson, RK
Waterston, RH
Miller, W
Green, ED
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) : 1172 - 1177
[10] Analysis of vertebrate SCL loci identifies conserved enhancers
Göttgens, B
Barton, LM
Gilbert, JGR
Bench, AJ
Sanchez, MJ
Bahn, S
Mistry, S
Grafham, D
McMurray, A
Vaudin, M
Amaya, E
Bentley, DR
Green, AR
[J]. NATURE BIOTECHNOLOGY, 2000, 18 (02) : 181 - 186

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