Mechanisms of inflammation in gout

被引：224

作者：

Busso, Nathalie ^{[1
]}

So, Alexander ^{[1
]}

机构：

[1] Univ Lausanne, CHU Vaudois, Serv Rheumatol, CH-1011 Lausanne, Switzerland

来源：

ARTHRITIS RESEARCH & THERAPY | 2010年 / 12卷 / 02期

关键词：

MONOSODIUM URATE CRYSTALS; NECROSIS-FACTOR-ALPHA; AIR POUCH MODEL; NALP3; INFLAMMASOME; NEUTROPHIL RECRUITMENT; MONOHYDRATE CRYSTALS; SYNOVIAL-FLUID; MAST-CELLS; ACTIVATION; COMPLEMENT;

D O I：

10.1186/ar2952

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1 beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.

引用

页数：8

共 51 条

[11] ACTIVATION OF THE ALTERNATIVE PATHWAY OF COMPLEMENT BY MONOSODIUM URATE CRYSTALS [J].

FIELDS, TR ;

ABRAMSON, SB ;

WEISSMANN, G ;

KAPLAN, AP ;

GHEBREHIWET, B .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1983, 26 (02) :249-257

[12] TREM and TREM-like receptors in inflammation and disease [J].

Ford, Jill W. ;

McVicar, Daniel W. .

CURRENT OPINION IN IMMUNOLOGY, 2009, 21 (01) :38-46

[13] INHIBITION OF LEUCOTRIENE-B4 SYNTHESIS BY BW-755C DOES NOT REDUCE POLYMORPHONUCLEAR LEUKOCYTE (PMNL) ACCUMULATION INDUCED BY MONOSODIUM URATE CRYSTALS [J].

FORREST, MJ ;

ZAMMIT, V ;

BROOKS, PM .

ANNALS OF THE RHEUMATIC DISEASES, 1988, 47 (03) :241-246

[14]

Getting SJ, 1997, J PHARMACOL EXP THER, V283, P123

[15]

GICLAS PC, 1979, J CLIN INVEST, V63, P759, DOI 10.1172/JCI109360

[16] MECHANISMS OF CELLULAR INTERACTION WITH MONOSODIUM URATE CRYSTALS - IGG-DEPENDENT AND IGG-INDEPENDENT PLATELET STIMULATION BY URATE CRYSTALS [J].

GINSBERG, MH ;

KOZIN, F .

ARTHRITIS AND RHEUMATISM, 1978, 21 (08) :896-903

[17] Caspase 1-Independent Activation of Interleukin-1β in Neutrophil-Predominant Inflammation [J].

Guma, Monica ;

Ronacher, Lisa ;

Liu-Bryan, Ru ;

Takai, Shinji ;

Karin, Michael ;

Corr, Maripat .

ARTHRITIS AND RHEUMATISM, 2009, 60 (12) :3642-3650

[18] INFLAMMATORY MICROCRYSTALS DIFFERENTIALLY REGULATE THE SECRETION OF MACROPHAGE INFLAMMATORY PROTEIN-1 AND INTERLEUKIN-8 BY HUMAN NEUTROPHILS - A POSSIBLE MECHANISM OF NEUTROPHIL RECRUITMENT TO SITES OF INFLAMMATION IN SYNOVITIS [J].

HACHICHA, M ;

NACCACHE, PH ;

MCCOLL, SR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :2019-2025

[19] MECHANISMS OF LYSOSOMAL ENZYME RELEASE FROM LEUKOCYTES .4. INTERACTION OF MONOSODIUM URATE CRYSTALS WITH DOGFISH AND HUMAN LEUKOCYTES [J].

HOFFSTEIN, S ;

WEISSMANN, G .

ARTHRITIS AND RHEUMATISM, 1975, 18 (02) :153-165

[20] Inflammatory Arthritis in Caspase 1 Gene-Deficient Mice Contribution of Proteinase 3 to Caspase 1-Independent Production of Bioactive Interleukin-1β [J].

Joosten, Leo A. B. ;

Netea, Mihai G. ;

Fantuzzi, Giamila ;

Koenders, Marije I. ;

Helsen, Monique M. A. ;

Sparrer, Helmut ;

Pham, Christine T. ;

van der Meer, Jos W. M. ;

Dinarello, Charles A. ;

van den Berg, Wim B. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (12) :3651-3662

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