Mechanisms of inflammation in gout

被引：224

作者：

Busso, Nathalie ^{[1
]}

So, Alexander ^{[1
]}

机构：

[1] Univ Lausanne, CHU Vaudois, Serv Rheumatol, CH-1011 Lausanne, Switzerland

来源：

ARTHRITIS RESEARCH & THERAPY | 2010年 / 12卷 / 02期

关键词：

MONOSODIUM URATE CRYSTALS; NECROSIS-FACTOR-ALPHA; AIR POUCH MODEL; NALP3; INFLAMMASOME; NEUTROPHIL RECRUITMENT; MONOHYDRATE CRYSTALS; SYNOVIAL-FLUID; MAST-CELLS; ACTIVATION; COMPLEMENT;

D O I：

10.1186/ar2952

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1 beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.

引用

页数：8

共 51 条

[41] Monosodium urate monohydrate crystal-induced inflammation in vivo -: Quantitative histomorphometric analysis of cellular events [J].

Schiltz, C ;

Lioté, F ;

Prudhommeaux, F ;

Meunier, A ;

Champy, R ;

Callebert, J ;

Bardin, T .

ARTHRITIS AND RHEUMATISM, 2002, 46 (06) :1643-1650

[42]

SCHUMACHER HR, 2009, ACR ANN M 2009

[43] Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals [J].

Scott, Peter ;

Ma, Hong ;

Viriyakosol, Suganya ;

Terkeltaub, Robert ;

Liu-Bryan, Ru .

JOURNAL OF IMMUNOLOGY, 2006, 177 (09) :6370-6378

[44]

SERHAN CN, 1984, PROSTAG OTH LIPID M, V27, P563, DOI 10.1016/0090-6980(84)90092-3

[45]

SO A, 2009, ACR ANN M 2009

[46] A pilot study of IL-1 inhibition by anakinra in acute gout [J].

So, Alexander ;

De Smedt, Thibaut ;

Revaz, Sylvie ;

Tschopp, Joerg .

ARTHRITIS RESEARCH & THERAPY, 2007, 9 (02)

[47] Severe gouty arthritis refractory to anti-inflammatory drugs:: treatment with anti-tumour necrosis factor α as a new therapeutic option [J].

Tausche, AK ;

Richter, K ;

Grässler, A ;

Hänsel, S ;

Roch, B ;

Schröder, HE .

ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 (10) :1351-1352

[48]

Terkeltaub R, 1998, ARTHRITIS RHEUM, V41, P900, DOI 10.1002/1529-0131(199805)41:5<900::AID-ART18>3.0.CO

[49]

2-K

[50] Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis [J].

Torres, R. ;

Macdonald, L. ;

Croll, S. D. ;

Reinhardt, J. ;

Dore, A. ;

Stevens, S. ;

Hylton, D. M. ;

Rudge, J. S. ;

Liu-Bryan, R. ;

Terkeltaub, R. A. ;

Yancopoulos, G. D. ;

Murphy, A. J. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (10) :1602-1608

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