Cryptosporidium parvum infection of human intestinal xenografts in SCID mice induces production of human tumor necrosis factor alpha and interleukin-8

被引:53
作者
Seydel, KB
Zhang, TH
Champion, GA
Fichtenbaum, C
Swanson, PE
Tzipori, S
Griffiths, JK
Stanley, SL
机构
[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[2] Univ Washington, Sch Med, Dept Med, St Louis, MO USA
[3] Univ Washington, Sch Med, Dept Pathol, St Louis, MO USA
[4] Tufts Univ, Sch Vet Med, Dept Biomed Sci, Div Infect Dis, Boston, MA 02111 USA
[5] Tufts Univ, Sch Med, Dept Family Hlth & Community Med, Boston, MA 02111 USA
关键词
D O I
10.1128/IAI.66.5.2379-2382.1998
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The protozoan parasite Cryptosporidium parvum invades intestinal epithelial cells and can cause life-threatening diarrhea in immunocompromised individuals. Despite the clinical importance of this organism, much remains to be learned about the pathogenesis of C. parvum-induced diarrhea. To explore the role of the intestinal inflammatory response in C. parvum disease, using C. parvum oocysts we infected human intestinal xenografts in severe combined immunodeficient (SCID) mice. Seven days after infection, we found levels of human tumor necrosis factor alpha and interleukin-8 in C. parvum-infected human intestinal xenografts that were significantly higher than those seen in uninfected control xenografts. These results demonstrate that human intestinal cells produce proinflammatory cytokines in response to C. parvum infection and establish SCID-HU-INT mice as a model system to study the interactions of C. parvum with the human intestine.
引用
收藏
页码:2379 / 2382
页数:4
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