Molecular insights into neurodevelopmental and neurodegenerative diseases

被引:21
作者
Pettegrew, JW
Klunk, WE
Panchalingam, K
McClure, RJ
Stanley, JA
机构
[1] Univ Pittsburgh, Sch Med, Neurophys Lab, Dept Psychiat, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Neurophys Lab, Dept Neurol, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Sch Med, Neurophys Lab, Dept Hlth Serv Adm, Pittsburgh, PA 15213 USA
关键词
magnetic resonance spectroscopy; Alzheimer's disease; neurodevelopment;
D O I
10.1016/S0361-9230(00)00376-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Magnetic resonance spectroscopy (MRS) is a noninvasive physical technique that is routinely used to determine the quantity and structure of organic molecules in solution, Technical advances that have expanded the usefulness of this technique include: (1) high resolution MRS to identify and quantify individual molecules present in complex mixtures of tissue extracts; (2) in vivo MRS techniques to non-invasively monitor metabolites in humans; (3) stucture determination of proteins of moderate size; and (4) improved structure characterization of solids and liquid crystals, such as the detection of phase changes in membranes. The focus of this review is on the first two technical advances mentioned above. The strengths of MRS as a research tool to investigate molecular alterations in disease states include ease of sample preparation, minimum sample manipulation, avoidance of the preparation of derivatives, and the ability to analyze an unfractionated sample. The strengths of MRS in the clinic are its ability to measure neuronal metabolite levels non-invasively in humans and its potential for disease diagnosis, monitoring disease progression, and assessing the efficacy of experimental therapies. (C) 2000 Elsevier Science Inc.
引用
收藏
页码:455 / 469
页数:15
相关论文
共 110 条
  • [81] CHANGES IN BRAIN MEMBRANE PHOSPHOLIPID AND HIGH-ENERGY PHOSPHATE-METABOLISM PRECEDE DEMENTIA
    PETTEGREW, JW
    KLUNK, WE
    KANAL, E
    PANCHALINGAM, K
    MCCLURE, RJ
    [J]. NEUROBIOLOGY OF AGING, 1995, 16 (06) : 973 - 975
  • [82] P-31 NUCLEAR MAGNETIC-RESONANCE STUDY OF THE BRAIN IN ALZHEIMERS-DISEASE
    PETTEGREW, JW
    MOOSSY, J
    WITHERS, G
    MCKEAG, D
    PANCHALINGAM, K
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1988, 47 (03) : 235 - 248
  • [83] Magnetic resonance spectroscopic changes in Alzheimer's disease
    Pettegrew, JW
    Klunk, WE
    Panchalingam, K
    McClure, RJ
    Stanley, JA
    [J]. CEREBROVASCULAR PATHOLOGY IN ALZHEIMER'S DISEASE, 1997, 826 : 282 - 306
  • [84] ALTERATIONS OF CEREBRAL METABOLISM IN PROBABLE ALZHEIMERS-DISEASE - A PRELIMINARY-STUDY
    PETTEGREW, JW
    PANCHALINGAM, K
    KLUNK, WE
    MCCLURE, RJ
    MUENZ, LR
    [J]. NEUROBIOLOGY OF AGING, 1994, 15 (01) : 117 - 132
  • [85] PETTEGREW JW, 1991, ARCH GEN PSYCHIAT, V48, P563
  • [86] PETTEGREW JW, 1987, J NEURAL TRANSM, P261
  • [87] CHANGES IN BRAIN ENERGY AND PHOSPHOLIPID-METABOLISM DURING DEVELOPMENT AND AGING IN THE FISCHER-344 RAT
    PETTEGREW, JW
    PANCHALINGAM, K
    WITHERS, G
    MCKEAG, D
    STRYCHOR, S
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1990, 49 (03) : 237 - 249
  • [88] CORRELATION OF P-31 MAGNETIC-RESONANCE SPECTROSCOPY AND MORPHOLOGIC FINDINGS IN ALZHEIMERS-DISEASE
    PETTEGREW, JW
    PANCHALINGAM, K
    MOOSSY, J
    MARTINEZ, J
    RAO, G
    BOLLER, F
    [J]. ARCHIVES OF NEUROLOGY, 1988, 45 (10) : 1093 - 1096
  • [89] PETTEGREW JW, 2000, SOC NEUR ABSTR, V26, P537
  • [90] APOLIPOPROTEIN-E POLYMORPHISM AND ALZHEIMERS-DISEASE
    POIRIER, J
    DAVIGNON, J
    BOUTHILLIER, D
    KOGAN, S
    BERTRAND, P
    GAUTHIER, S
    [J]. LANCET, 1993, 342 (8873) : 697 - 699